Aspirin

 Aspirin ( acetyl salicylic acid), first isolated by a german chemist, is one of the widely-used NSAIDs allover the world.

Aspirin has been used for a variety of purposes, for ex.:

1-common cold as analgesic.

2-anti-rheumatic and for fever as anti-inflammatory and anti-pyretic.

3-prevention of complicated cardiovascular events, due to it's anti-platelet activity.SO, aspirin should be used with caution when used with anti-platelet drugs like clopidogril and warfarin as it would lead to bleeding

4-reducing catract in diabetic patients, but it's not so effective for that purpose.

Mechanism of action:

inhibition of COX-1 and COX-2 enzymes to reduce production of prostaglandins and stop inflammation.

USE WITH CAUTION IF1- sensitive to ibuprofen or have peptic ulcer.

                                           2-using other NSAIDs.

                                           3- using anti-platelet drugs.

New forms of aspirin have been produced for more safety on stomach like effervescent granules.

Interactions; replaces tolbutamide(anti-diabetic), valporic acid, phenytoin(anti-convulsant), and probencid.